In a world where Reapers prey on the souls of the living, imprisoning them in the shadow-land of Mortem, there is one last hope for humanity. Her name is September Mourning. Half human, half Reaper, she takes the souls of the wicked so the innocent can live again. September has joined forces with a woman who was murdered and restored to life, and a young blind girl who sees only the dead. Together, as The Trinity, they set out to fulfill a prophecy...

"A Tale of Three Brothers" continues as Al Simmons becomes a cold-blooded killer, while his brothers follow their own paths, one to become a man of justice, the other descending into drug addiction and mental breakdown. As the memories flood back, Spawn begins to realize that it was no accident that he was chosen to become a Hellspawn.

Desperate to regain her powers of magick, Nyx seeks help among the Voudou community of New Orleans. But the price she has to pay proves too high. Only Spawn can save her from the evil she encounters. The problem is, the last time they met, Spawn swore to kill her if their paths ever crossed again. Poor Nyx. Out of the cauldron and into the fire.

As Spawn continues to explore the past, he finds that Mammon's influence on the Simmons' family goes back further than he has imagined. Al Simmons' great-great-grandfather was a Buffalo Soldier, but what happened when this hero of the Old West crossed paths with an emissary from Hell? Two words: Gunslinger Spawn!

Spawn faces his greatest challenge -_ The Disciple. Armageddon is approaching fast and with Heaven's new recruits lining up for battle, Hell is going to need to swell its ranks too. And where is it going to find the cruelest, most ruthless, kick-ass SOB's on the face of the Earth? Burn, Hollywood, BURN!

The Angel Zera takes on the Forgotten in a battle to control the hosts of heaven. On Earth Kali lays waste to India and Spawn learns that as the End Time approaches some of the most terrible creatures of mythology are about to be unleashed. Meanwhile Sam and Twitch uncover the shocking truth about Spawn's inner demons.

Issue 165 breaks continuity and features a Mandarin Spawn one-shot. Lan Medina, part of the Eisner award-winning team on Fables, is doing the art honors. The Mandarin Spawn action figure has long been a fan favorite, and in response to their requests over the years, this issue provides the origin of the character.

"New Beginnings" - Horror has a new face. Murder, suicide, self-mutilation, mental breakdown; New Vista Apartments has a higher death rate than downtown Baghdad. But no one wants to leave. Spawn discovers there really is no peace for the wicked.

Spawn battles his inner demon. Is he a force for Good or Evil? If Evil wins, Wanda dies. If Good triumphs, this is the end of Spawn. We mean it!

When Spawn re-made the world he closed the portals to Heaven and Hell. With no fresh souls to torment, the demons are getting restless. In this issue, the door is breached. One man faces judgement and if he is guilty the price will be a one-way ticket to eternal damnation.