In a world where Reapers prey on the souls of the living, imprisoning them in the shadow-land of Mortem, there is one last hope for humanity. Her name is September Mourning. Half human, half Reaper, she takes the souls of the wicked so the innocent can live again. September has joined forces with a woman who was murdered and restored to life, and a young blind girl who sees only the dead. Together, as The Trinity, they set out to fulfill a prophecy...

Issue 165 breaks continuity and features a Mandarin Spawn one-shot. Lan Medina, part of the Eisner award-winning team on Fables, is doing the art honors. The Mandarin Spawn action figure has long been a fan favorite, and in response to their requests over the years, this issue provides the origin of the character.

The new world that has been created by Spawn begins in this issue. It seems as if the world is more than perfect, but the cracks are starting to appear, as the new world begins to show its true colors.

War is Hell. France, July 1st 1916 the bloodiest day in the history of human conflict. On the battlefield of the Somme, one man makes the ultimate sacrifice. A new Hellspawn is born and the dead rise to follow him into endless war.

People are dying and witnesses swear the killer is a ghost. Police profiler Marc Simmons thinks he knows better, but his suspect has the perfect alibi. Can Spawn solve the riddle of 'The Monster in the Bubble'?

In Memphis, Tennessee the dead are rising from their graves. Spawn morphs into a gun- toting killing machine this has more exploding heads than any Arcade shoot-em-up you ever played! Meanwhile, the goddess Kali is doing some headhunting of her own, while the Forgotten Ones make a bid to take control of Heaven. And if that isn't enough, meet Zera the roughest, toughest, sexiest angel yet.

In the depths of hell Spawn faces torture at the hands of The Grand Inquisitor Thamuz, who has sworn to uncover Spawn's deepest secret or tear his soul apart trying. Meanwhile a thirteen-year-old boy is sent on a simple quest, unaware that the fate of mankind lies in his hands.

As Spawn continues to explore the past, he finds that Mammon's influence on the Simmons' family goes back further than he has imagined. Al Simmons' great-great-grandfather was a Buffalo Soldier, but what happened when this hero of the Old West crossed paths with an emissary from Hell? Two words: Gunslinger Spawn!

Desperate to regain her powers of magick, Nyx seeks help among the Voudou community of New Orleans. But the price she has to pay proves too high. Only Spawn can save her from the evil she encounters. The problem is, the last time they met, Spawn swore to kill her if their paths ever crossed again. Poor Nyx. Out of the cauldron and into the fire.

This is the big one: Armageddon! Not a trick, not an imaginary story: The end of the world is at hand. God and Satan go head to head in the Final Conflict and as Spawn's counter heads towards zero, it looks like he is about to lose the battle to save the human race.